代谢综合征血脂异常的特点及治疗研究进展

Characteristics of and Therapy for Dyslipidemia in Metabolic Syndrome

代谢综合征具有多种心血管疾病的危险因素。其核心成分之一血脂异常易致动脉粥样硬化,主要有高三酰甘油、低高密度脂蛋白胆固醇和小而密低密度脂蛋白胆固醇升高。降脂治疗的基本措施是改善生活方式,药物治疗包括他汀类、贝特类、烟酸、依折麦布、胆固醇酯转运蛋白抑制剂等及联合治疗。

The metabolic syndrome is a multiplex risk factor for atherosclerotic cardiovascular disease.The core components of the dyslipidemia of the metabolic syndrome are the ＂lipid triad＂ of high plasma triglycerides,low levels of high-density lipoprotein cholesterol,and many small,dense low-density lipoprotein particles.The cornerstone of therapy for this is lifestyle change.If this does not correct the dyslipidemia,drug therapy may be required.Several drugs have been described for the management of the dyslipidemia including fibrates,ezetimibe,niacin,cholesteryl ester transfer protein inhibitors,as well as combined treatment regimes.