85例老年药物性肝炎患者临床分析

Clinical analysis of 85 elderly patients with drug-induced liver disease

目的分析老年人药物性肝炎的临床特点、药物种类及防治原则。方法对85例老年和87例非老年药物性肝炎患者进行回顾性临床对照分析。结果在老年药物性肝炎患者,由中(成)草药引起的42例(49.4%),抗生素28例(32.9%),抗结核药7例(8.2%),其他8例(9.4%);肝细胞型38例(44.5%),胆汁淤积型34例(40.0%),混合型13例(15.3%),死亡4例(4.7%);在非老年患者,抗结核药38例(43.7%),抗生素26例(29.9%),中(成)草药15例(17.2%),其他7例(8.0%);肝细胞型58例(66.7%),胆汁淤积型18例(20.7%),混合型11例(12.6%),无一例死亡。结论中草药和抗生素是引起老年人药物性肝损害的常见药物。应用中草药和抗生素的老年人应定期检测肝功能。

Objective To investigate the clinical characteristics in elderly patients with drug-induced liver injury.Methods 85 elderly and 87 non-elderly patients with drug-induced liver injury were retrospectively studied.Results The top three drugs in elderly patients were Chinese herbal medicine（49.4%）,antibiotics（32.9%）and antituberculous agents（8.2%）;The cholestasis was found in 40.0% of elderly patients,while only 20.7% in non-elderly patients.Conclusion The Chinese herbal medicine and antibiotics are common agents causing elderly hepatic injury.