青壮年冠心病合并焦虑抑郁症的临床研究

Clinical study of on young adults of coronary heart disease accompanied with depression and anxiety

目的:探讨青壮年冠心病合并焦虑抑郁症的发病及治疗。方法:将272例青壮年冠心病患者采用Zung氏焦虑自评量表(SAS)及抑郁自评量表(SDS)评定焦虑抑郁情绪,检出合并焦虑抑郁症者72例,将其随机分为对照组和治疗组,前者给予常规治疗,后者在常规治疗同时加用抗抑郁药物氟西汀胶囊。观察8周。于治疗前及治疗第8周末进行对比分析。结果:治疗组在治疗8周末SAS及SDS评分较治疗前及对照组均显著下降(P<0.05),心绞痛、心律失常、心肌梗死及心源性猝死发生率明显降低(P<0.05)。结论:青壮年冠心病合并焦虑抑郁症患者同时加用抗焦虑、抗抑郁药物,其疗效显著优于常规治疗。

Objective：To explore the incidence and treatment of young adults of coronary heart disease accompanied with depression and anxiety.Methods：272 young adults coronary heart disease were enrolled in this study.72 cases were founded accompanied with depression and anxiety by the Zung Self-Rating Anxiety Scale（SAS） and the Zung Self-Rating Depression Scale（SDS）.They were randomly divided into research groupreceiving Fluoxetine Hydrochlorlde Capsules plus routine treatment and control group doing routine treatment for 8 weeks.Before treatment and at the and of the 8 weeks treatment,comparisons and analyses conducted.Results：At the end of the eighth week,the SAS and SDS score significantly lowered compared with pretreatment in the research group（P0.05） and compared with the control group（P0.05）.At the end of the eighth week,the rates of angina,arrhythmia,myocardial infarction,sudden cardiac in the research group were significantly lower than that in the control group（P0.05）.Conclusion：The application of Fluoxetine Hydrochlorlde Capsules plus routine treatment in the treatment of anxiety-depression patients is better than the routine treatment.