祛瘀通脉胶囊活血化瘀作用的实验研究

An Experimental Study on the Blood Circulation Function of Quyutongmai Capsule

目的:研究祛瘀通脉胶囊的活血化瘀作用。方法:采用大鼠急性血瘀高分子右旋糖苷复制模型,在体ADP诱导家兔血小板聚集、"胶原蛋白-肾上腺素"致小鼠体内血栓形成和小鼠耳廓微循环4种实验方法,对祛瘀通脉胶囊的活血化瘀作用进行研究。结果:祛瘀通脉胶囊灌胃给药,连续8 d,在0.62、0.31 g/kg剂量下能显著降低血瘀(10%右旋糖酐诱导)大鼠的全血粘度和血浆粘度。在0.31、0.155 g/kg剂量能显著抑制ADP诱导的家兔血小板聚集。在1.23、0.62g/kg的剂量下能对抗胶原蛋白-肾上腺素混合诱导剂引起的小鼠体内血栓形成,减少动物的死亡数并使偏瘫恢复正常。祛瘀通脉胶囊单次灌胃给药,在1.23 g/kg的剂量下,能使小鼠耳廓的微动脉和微静脉管口径显著增大。结论:祛瘀通脉胶囊具有活血化瘀的作用。

Objective: To study the blood-activiating and stasis-dissolving effect of Quyutongmai Capsule.Methods: The dextran polymer copy model of acute blood stasis rats,the platelet aggregation of rabbits in vivo induced by ADP,the thrombosis in mice by collagen-adrenaline,and microcirculation of mouse experiments were used to test the activating blood and dissolving stasis effect of Quyutongmai Capsule.Results: Quyutongmai Capsule was given by gastric perfusion for 8 days,and significantly decreased the blood stasis(10% dextran) of the whole blood viscosity and plasma viscosity of the rats at the dose of 0.62 and 0.31 g/kg and significantly inhibited the platelet aggregation induced by ADP at the dose of 1.23 and 0.62 g/kg and can confront the mice thrombosis induced by collagen-adrenaline mixture,thus reducing the number of deaths of animals and making hemiplegia back to normal.A single intragastric administration of Quyutongmai Capsule could significantly increase the diameters of the arterioles and venules pipe of the mouse ears at the dose of 1.23 g/kg.Conclusion: Quyutongmai Capsule has a blood-activiating and stasis-dissolving effect.