2000—2009年我院抗感染药物利用动态分析

Dynamic Analysis of Antimicrobial Agents Used in Our Hospital during Period 2000 — 2009

目的了解抗感染药物利用状况和发展趋势,为其合理应用及科学监管提供理论依据。方法采用用药频度(DDDs)分析法及消耗金额统计法,对2000年至2009年间抗感染药物DDDs及消耗金额进行统计排序,对各类抗感染药物的临床地位及应用情况进行系统评价分析。结果药品销售总金额逐年上升,抗感染药物销售占西药销售总金额的比例逐年下降;头孢菌素类临床使用份额最高,占主导地位;注射用阿奇霉素和头孢哌酮舒巴坦分别连续3年居药品销售首位。10年中销售居前3位达3年的药物有头孢曲松、克林霉素、美洛西林舒巴坦及左氧氟沙星注射剂等。结论近两年头孢米诺销售金额跃居首位,提示这些抗菌药物价位较高且临床使用范围广,因此应加强监管、建立预警机制以防止滥用,避免细菌耐药性过快增长。

Objective To understand the current situation and future developing trend of the use of antimicrobial agents so as to provide the theoretical basis for rational clinical use of antibacterial drugs and scientific supervision of clinical application of drugs.Methods By using the statistic method of order of consumption amount and DDDs,the use frequency and consumption amount of antimicrobial agents used in our hospital during period 2000-2009 were statistically sorted,and their clinical position and application status were systematically analyzed and evaluated.Results During 10 years,the total consumption amount of antimicrobial agents were increased year by year,while the proportion of consumption amount of antimicrobial agents to the total consumption of western medicines was decreased year by year.Cephalosporins shared the highest in clinical drug using,azithromycin injection and cefoperaxone sodium/sulbactam occupied the first sale in successive 3 years.Ceftriaxone,clindamycin,mezlocillin/sulbactam and levofloxacin agents took the top 3 places in successive 3 years.Conclusion Cefminox ranks the top in nearly 2 years,suggesting that these antimicrobial agents are priced higher and wide range of clinical use,the supervision should be strengthened and the early warning mechanisms should be established to prevent abuse and avoid the excessive increase of bacterial drug resistance.