格列喹酮与格列齐特的临床疗效及不良反应比较

Clinical Effect and Adverse Reaction of Gliquidone and Gliclazide

目的回顾性分析对比格列喹酮与格列齐特的临床疗效及不良反应。方法将丽水市中心医院内分泌科用过格列喹酮和格列齐特两种药物3个月以上的门诊和住院患者129例的病历资料及化验单进行统计分析,比较用药后空腹血糖、餐后2 h血糖及肝肾功能等指标。结果两组治疗3个月后空腹血糖均明显下降(P<0.05),格列齐特降空腹血糖效果优于格列喹酮,格列喹酮降餐后2 h血糖作用优于格列齐特;两组肝肾功能各项指标无大的波动,不良反应发生率无显著性差异。结论格列喹酮和格列齐特都有一定的降血糖疗效,格列喹酮不良反应较格列齐特少,且对肾功能具有一定的保护作用。

Objective To review and analyze the clinical curative effect and adverse reaction of gliquidone and gliclazide.Methods One hundred and twenty-nine inpatients and outpatients in Lishui Center Hospital were statistically analyzed on medical records and lab reports in using gliquidone and gliclazide.To compare the indicators of FBG,2 h PBG,hepatorenal function.Results After 3 months of treatment,the FBG of gliquidone group and gliclazide group was significantly reduced（P 0.05）,and the gliclazide group was better than the gliquidone.The reducing effect of 2 h PBG in the gliquidone group was better than that in the gliclazine group.The hepatorenal function of the two groups had little change,and the adverse reaction of the two groups was not significantly different.Conclusion There is hypoglycemic effect in gliquidone and gliclazide.Gliquidone has fewer adverse reactions than gliclazine,and has certain protective effect to the renal function.