冠心病患者血清尿酸和C反应蛋白联合检测的临床意义探讨

Serum levels of uric acid,C reactive protein and its clinical significance

目的探讨冠心病患者血清尿酸和C反应蛋白联合检测的临床意义,及二者之间的相关性。方法选择我院2007年1月～2009年1月经冠状动脉造影确诊(CAG)为冠心病的患者84例作为研究对象,另选80例健康体检者作为健康对照组,分别采用尿酸酶比色法、免疫比浊法检测两组患者的血清尿酸(UA)及C反应蛋白(CRP)的变化水平,以及探讨二者之间的相关性。结果稳定型心绞痛组的UA水平与健康对照组比较,差异无统计学意义(P>0.05)。不稳定型心绞痛组、心肌梗死组的UA水平与健康对照组比较,差异有统计学意义(P<0.01),稳定型心绞痛组、不稳定型心绞痛组、心肌梗死组三组CRP水平分别与健康对照组比较,差异有统计学意义(P<0.01)。冠心病不稳定型心绞痛患者血清UA、CRP水平作直线相关分析,结果显示,二者呈明显正相关(r=0.872,P<0.01)说明不稳定性心绞痛患者血浆随着CRP水平的升高,UA水平也随之升高。结论 UA和CRP可以作为心血管病的一个危险因子,与心血管病其它指标联合检测在心血管病的早期诊断和预后判断上具有重要作用,值得在临床推广使用。

Objective To investigate the serum levels of uric acid and C reactive protein and its clinical significance,and the correlation between the two.Methods In our hospital in January 2007~2009 period on a coronary angiography（CAG） for the 84 patients with coronary heart disease as an object of study,choose another 80 healthy volunteers as control group were treated with immune turbidimetry,uricase colorimetric assay of serum uric acid groups（UA） and C-reactive protein（CRP） level changes,and to explore the correlation between the two.Results Stable angina group UA levels and health control group,the difference was not statistically significant（P0.05）.Unstable angina,myocardial infarction,UA group compared with healthy control group,the difference was significant（P0.01）,stable angina,unstable angina,myocardial infarction three CRP levels were compared with healthy control group,the difference was significant（P0.01）.Patients with unstable angina UA,CRP levels for linear correlation analysis showed that both positively correlated（r=0.872,P0.01） shows patients with unstable angina pectoris with CRP levels The increase,UA levels with an increasing.Conclusion UA and CRP as a risk factor for cardiovascular disease,and cardiovascular disease other heart disease markers in early diagnosis and prognosis play an important role on the worth in clinical use.