病毒感染与扩张型心肌病关系的临床研究

Clinical observation of relationship between dilated cardiomyopathy and viral infection

目的探讨甲、乙、丙型肝炎病毒感染以及人类免疫缺陷病毒与扩张型心肌病发病之间的关系。方法纳入经病史、临床症状、体征、超声心动图和冠状动脉造影确诊的扩张型心肌病患者(DCM组)130例,并同时调查同期冠状动脉造影阴性的心律失常或心血管神经症患者(对照组)351例,收集一般临床特征资料以及甲、乙、丙型肝炎病毒抗原、抗体检测结果和人类免疫缺陷病毒初筛抗体结果,并进行统计分析。结果对照组甲型肝炎病毒抗体(HAVAb)、乙型肝炎表面抗原(HBsAg)、乙型肝炎表面抗体(HBsAb)、乙型肝炎e抗原(HBeAg)、乙型肝炎e抗体(HBeAb)、乙型肝炎核心抗体(HBcAb)、丙型肝炎抗体(HCVAb)、人类免疫缺陷病毒抗体(HIVAb)阳性患者分别为0、10、150、1、26、47、3、0;DCM组HAVAb、HBsAg、HBsAb、HBeAg、HBeAb、HBcAb、HCVAb、HIVAb阳性患者分别为0、5、54、0、11、16、2、0;两组差异无统计学意义(均P>0.05)。结论在中国人中甲、乙、丙型肝炎病毒感染以及人类免疫缺陷病毒与DCM发病之间不存在明确的关系,上述病毒感染可能不是DCM的发病原因。

Objective To explore the relationship between viral infection,including hepatitis A,B,C virus and human immunodeficiency virus（HIV）,and morbility of dilated cardiomyopathy（DCM）.Methods General clinical character,viral antigen,antibody of hepatitis A,B,C virus and HIV were investigated on 130 DCM patients（DCM group） that definited by history,clinical symptom,physical sign,ultrasound cardiogram and coronary artery angiography and 351 arrhythmia or cardiovascular neurosis patients（control group） who got at the sametime negative results in coronary artery angiography,then statistical analysis was conducted.Results There were 0,10,150,1,26,47,3,0 of HAVAb,HBsAg,HBsAb,HBeAg,HBeAb,HBcAb,HCVAb,HIVAb positive patients in the control group respectively,and 0,5,54,0,11,16,2,0 patients in the DCM group respectively.There were no significant difference between two groups by statistical analysis.Conclusion There are no relationship between viral infection including hepatitis A,B,C virus and HIV and morbility of DCM in Chinese.