亚低温治疗对重型颅脑损伤患者预后及其脑脊液中Aβ水平的影响

Influence of moderate hypothermia on cerebrospinal fluid amyloid β peptide level and prognosis in severe traumatic brain injury patients

目的观察亚低温治疗对重型颅脑损伤(sTBI)患者预后及其脑脊液(CSF)中β淀粉样蛋白(Aβ)水平的影响,并探讨其意义。方法将60例sTBI随机分为观察组和对照组各30例,观察组采用亚低温治疗,对照组采用常温治疗;采用双抗体夹心ELISA法检测治疗前及治疗后第1、3、5、7天患者CSF中的Aβ,3个月后行GOS评定预后。结果对照组CSF中的Aβ水平逐渐升高,而观察组Aβ水平逐渐降低;治疗后3、5、7 d,两组AB水平比较,P均<0.01。治疗后3个月观察组GOS为(4.3±0.4)分,对照组为(2.2±0.2)分,两组比较,P<0.05。结论亚低温治疗可明显改善sTBI患者的预后,可能与其降低患者CSF中的Aβ水平有关。

Objective To study the effects of moderate hypothermia on cerebrospinal fluid amyloid 13 （Aβ） peptide level and prognosis in severe traumatic brain injury （sTBI） patients. Methods 60 sTB1 patients were randomly divided into observe group and control group,30 cases each. Patient in observe group were treated with moderate hypothermia. Aβ in cerebrospinal fluid was detected by ELISA at 1,3,5,7 days, and prognosis were evaluated by GOS. Results Aβ in cerebrospinal fluid increased time-dependent in control group ,but decreased time-dependent in observe group. GOS scroll was 4.3 ± 0.4 in observe group, and 2.2 ± 0.2 in control group （ P 〈 0.05 ）. Conclusion Moderate hypothermia can inhabite the expression of Aβ and improve the clinical prognosis.