食管癌患者放疗前后血清转化生长因子β_1的变化及临床意义

The clinic significance of the changes of serum transforming growth factor 1 before and after radiotherapy in esophageal carcinoma patients

目的探讨食管癌放疗前后血清转化生长因子β１（ＴＧＦβ１）水平改变与放疗疗效及预后的关系。方法：采用ＥＬＩＳＡ方法检测５６例明确诊断的食管癌患者放疗前后的血清ＴＧＦβ１水平，并将其与病变范围、部位、Ｘ线病理分型、近期疗效及转移复发的关系进行对比分析。结果：放疗前食管癌患者血清ＴＧＦβ１平均水平明显高于正常对照组（Ｐ＜０．０１），血清ＴＧＦβ１的表达与病变部位、病变长度、Ｘ线病理分型无关（Ｐ＞０．０５）；放疗后血清ＴＧＦβ１水平下降（Ｐ＜０．０５），其改变与近期疗效及转移复发相关（Ｐ＜０．０１）。结论：血清ＴＧＦβ１水平可作为监测食管癌近期放疗疗效和预后、提示后续或辅助治疗的一项参考指标。

Objective: To evaluate the relation between the changes of serum transforming growth factor beta1 (TGF1) and response to radiotherapy in esophageal carcinoma before and after radiotherapy. Methods: Fifty six newly diagnosed esophageal carcinoma patients were studied. Serum samples for TGF1 were obtained before and after radiotherapy. An enzymelined immunosorbent assay(ELISA) was used to measure changes of serum TGF1 levels and compared with the limits, location, Xray pathologic, the immediate response to radiotherapy, metastasis and recurrence. Results: The data showed that the serum TGF1 level in esophageal carcinoma patients before radiotherapy was significantly higher than that of healthy controls(P<0.01).The changes of serum levels after radiotherapy were also closely related to the limits, the immediate response to radiotherapy and metastasis and recurrence(P<0.01), but were not related to the location, Xray pathological pattern of the lesions. Conclusion: These results suggest that the serum TGF1 level may be a useful marker for monitoring the response and prognosis after radiotherapy in patients with esophageal carcinoma.