摘要
目的 探讨住院糖尿病患者甲状腺过氧化物酶抗体(TPO-Ab)阳性率情况.方法 对1508例2型糖尿病(T2DM)、76例典型1型糖尿病(T1DM)、44例成人隐匿性自身免疫糖尿病(LADA)和256例未分型糖尿病(NTDM)患者进行TPO-Ab检测,并做好临床资料的登记和分析比对.结果 ①T2DM患者TPO-Ab的阳性率为14.59%(220/1508),典型T1DM组为42.11%(32/76)、NTDM组为31.25%(80/256)、LADA组为63.64%(28/44),与LADA组相比差异有统计学意义(P均<0.05),而与典型T1DM、NTDM组间差异无统计学意义(P均>0.05).②LADA与NTDM组相比,年龄、病程、BMI差异均无统计学意义(P均>0.05).结论 ①NTDM组TPO-Ab阳性率高于T2DM组,但低于典型T1DM组和LADA组.②LADA组的患者TPO-Ab阳性率最高,提示LADA与自身免疫甲状腺炎患病机制的共同性.③TPO-Ab的阳性率从T2DM、NTDM、典型T1DM及LADA呈连续递增趋势.
Objective To investigate the positive rate of thyroid peroxidase antibody(TPO-Ab) in the diabetic in-patients. Methods The positive rates of thyroid peroxidase antibody ( TPO-Ab ) was measured in 1884 subjects, including 1508 type 2 diabetes mellitus ( T2DM ), 76 classic typetype 1 diabeties( T1 DM ), 44 latent autoimmune diabetes in adults (LADA) and 256 "untype" diabetics ( NTDM ). Clinical data were registered and analyzed. Results( 1 )The positive rates of TPO-Ab were 14. 59% in T2DM(220/1508) ,42. 11% in T1DM (32/76) ,31.25% in NTDM ( 80/256 ), 63.64% in LADA group ( 28/44 ), respectively. The positive rate of T2DM was significantly lower than that of LADA ( P 〈 0. 05 ), but no significant difference was found in the coparison between T1 DM and NTDM ( P 〉 0. 05 ). ( 2 ) There were no significant differences between LADA and NTDM groups in the comparison of age, course of disease and BMI ( Ps 〉 0. 05 ). Conclusion ①The positive rate of TPO-Ab in NTDM was significantly higher than that of T2DM, whereas significantly lower than that of T1 DM and LADA.②The positive rate of TPO-Ab was highest in LADA, which indicate that LADA and AIT might have the common etiological mechanisms. ③There is a consisted increasing trend in the positive rate of TPO-Ab from T2DM ,NTDM,and classic T1DM to LADA.
出处
《中国综合临床》
2011年第1期62-65,共4页
Clinical Medicine of China