1884例住院糖尿病患者甲状腺过氧化物酶抗体阳性率检测分析

Positive prevalence of thyroid peroxidase antibody in 1884 diabetic in-patients

目的 探讨住院糖尿病患者甲状腺过氧化物酶抗体（TPO-Ab）阳性率情况.方法 对1508例2型糖尿病（T2DM）、76例典型1型糖尿病（T1DM）、44例成人隐匿性自身免疫糖尿病（LADA）和256例未分型糖尿病（NTDM）患者进行TPO-Ab检测,并做好临床资料的登记和分析比对.结果 ①T2DM患者TPO-Ab的阳性率为14.59%（220/1508）,典型T1DM组为42.11%（32/76）、NTDM组为31.25%（80/256）、LADA组为63.64%（28/44）,与LADA组相比差异有统计学意义（P均＜0.05）,而与典型T1DM、NTDM组间差异无统计学意义（P均＞0.05）.②LADA与NTDM组相比,年龄、病程、BMI差异均无统计学意义（P均＞0.05）.结论 ①NTDM组TPO-Ab阳性率高于T2DM组,但低于典型T1DM组和LADA组.②LADA组的患者TPO-Ab阳性率最高,提示LADA与自身免疫甲状腺炎患病机制的共同性.③TPO-Ab的阳性率从T2DM、NTDM、典型T1DM及LADA呈连续递增趋势.

Objective To investigate the positive rate of thyroid peroxidase antibody（TPO-Ab） in the diabetic in-patients. Methods The positive rates of thyroid peroxidase antibody （ TPO-Ab ） was measured in 1884 subjects, including 1508 type 2 diabetes mellitus （ T2DM ）, 76 classic typetype 1 diabeties（ T1 DM ）, 44 latent autoimmune diabetes in adults （LADA） and 256 ＂untype＂ diabetics （ NTDM ）. Clinical data were registered and analyzed. Results（ 1 ）The positive rates of TPO-Ab were 14. 59% in T2DM（220/1508） ,42. 11% in T1DM （32/76） ,31.25% in NTDM （ 80/256 ）, 63.64% in LADA group （ 28/44 ）, respectively. The positive rate of T2DM was significantly lower than that of LADA （ P 〈 0. 05 ）, but no significant difference was found in the coparison between T1 DM and NTDM （ P 〉 0. 05 ）. （ 2 ） There were no significant differences between LADA and NTDM groups in the comparison of age, course of disease and BMI （ Ps 〉 0. 05 ）. Conclusion ①The positive rate of TPO-Ab in NTDM was significantly higher than that of T2DM, whereas significantly lower than that of T1 DM and LADA.②The positive rate of TPO-Ab was highest in LADA, which indicate that LADA and AIT might have the common etiological mechanisms. ③There is a consisted increasing trend in the positive rate of TPO-Ab from T2DM ,NTDM,and classic T1DM to LADA.