胸腺因子D对白血病IL-6和TNF的调控作用

THYMIC FACTOR D REGUALTES THE IL 6 AND TNF IN ACUTE LEUKEMIA

探讨胸腺因子Ｄ（ＴＦＤ）对白血病患者白介素６（ＩＬ－６）和肿瘤坏死因子（ＴＮＦ）的调控作用，以便在白血病治疗中正确使用ＴＦＤ。在白血病化疗同时，加用ＴＦＤ５０ｍｇ＋１０％葡萄糖注射液５００ｍｌ，ＶＤ，ｑｄ×３ｍｏｎ，检测治疗前后ＩＬ－６活性和ＴＮＦ水平。结果：急性淋巴细胞性白血病（ＡＬＬ）和急性非淋巴细胞白血病（ＡＮＬＬ）的ＩＬ－６和ＴＮＦ均比正常对照组高（Ｐ＜０．０１）。化疗加用ＴＦＤ治疗后，ＡＬＬ的ＩＬ－６和ＴＮＦ及ＡＮＬＬ的ＴＮＦ均比治疗前和化疗组显著降低。ＴＦＤ加化疗药物联合应用，可能是白血病的有效治疗方法。

To explore the regulatory effects of thymic factor D(TFD) on the interleukin 6(IL 6) and tumour necrosis factor (TNF). IL 6 and TNF level was determined in 42 patients with various type of acute leukemia. When TFD 50mg+10% glucose solution 500ml, iv.gtt, gd×3mo. to combine with chemotherapy treatment, compared with chemotherapy alone. In comparison with normal subjects, IL 6 activity and TNF level were significantly elevated in patients with acute lymphocytes leukemia(ALL) and non acute lymphocytes leukemia(NALL) ( P <0.01). IL 6 activity and TNF level in ALL and TNF in NALL were significantly decreased with TFD combined treatment compared with chemotherapy alone.These suggest that TFD combined with chemotherapy treatment can be favored of acute leukemia.