摘要
目的:探讨缓退瘤(Flutamide)与手术或药物去势联合治疗前列腺癌的疗效。方法:回顾性分析18例手术或药物去势联合缓退瘤治疗的前列腺癌患者的临床资料。结果:病理确诊后14例行手术去势及缓退瘤治疗,4例行药物去势加缓退瘤治疗,16例获得显著效果,1例出现肝功能损害,1例出现缓退瘤撤除综合征。结论:联合治疗可最大限度地阻断雄激素对前列腺的作用,使前列腺癌细胞迅速凋亡,从而延长患者的生存期。
Purpose: To inquire into the curative effects of prostatic cancer treated by the combination of flutamide with orchiectomy or medical castration. Methods: 18 cases of prostatic cancer undergoing combination treatment were analyzed retrospectively. Results: The patients with histopathologically identified prostatic cancer were followed up for 1239 months.16 cases achieved significant effects,1 showed impaired liver function and another the flutamide withdrawl syndrome. Conclusions: The combination treatment could bring about maximal androgen withdrawl and induced apoptosis of prostatic cancer cells,which may improve the survival of the patients.
出处
《临床泌尿外科杂志》
1999年第7期293-295,共3页
Journal of Clinical Urology