胎儿纤维连接蛋白与细菌性阴道病和绒毛膜羊膜炎关系的研究

The Relationship between Fetal Fibronectin, Bacteria Vaginosis and Chorioammionitis

目的通过检测胎儿纤连蛋白（ＦＦＮ）研究细菌性阴道病和绒毛膜羊膜炎的关系，为产前早期诊断绒毛膜羊膜炎提供新方法。方法采用酶联免疫吸附法（ＥＬＩＳＡ）对细菌性阴道病患者６０例（研究组），健康孕妇４５例（对照组）进行宫颈阴道分泌物ＦＦＮ检测。以ＦＦＮ≥５０μｇ／Ｌ为判断阳性标准。结果研究组ＦＦＮ阳性率２６．６７％（１６／６０），明显高于对照组ＦＦＮ阳性率的４．４％（２／４５），两组比较，差异有极显著性（Ｐ＜０．００５）。研究组中ＦＦＮ（阳性）者的绒毛膜羊膜炎发生率为７５％（１２／１６），明显高于ＦＦＮ（阴性）者绒毛膜羊膜炎发生率的１３．６５％（６／４４），两组比较，差异有极显著性（Ｐ＜０．００１），且研究组中易发生早产和胎膜早破。结论ＦＦＮ与细菌性阴道病有关系，对产前诊断绒毛膜羊膜炎有价值，为预防胎膜早破和早产提供了有效的监测手段。

Objective To study the relationship of fetal fibronectin (FFN), Bacteria vaginosis (BV) and chorioamnionitis. To evaluate the diagnostic value of FFN for chorioamnionitis. Methods FFN was measured by enzymelabelled immunosordent assay (ELISA) in samples of carvical secretion from 60 pregnant women with BV (study group) and 45 normal pregnant women at same gestational weeks (control group). Positive test was defined as a level of (FFN)50 ng/ml. Results Positive rate of FFN in pregnant women with BV was significantly higher than that in the normal control group. Incidence of chorioamnionitis and preterm labor in FFN positive cases was significantly higher than that of FFN negative cases. Conclusions Fetal fibronectin is an important marker for diagnosis and prediction of chorioamnionitis perterm labor and Premature rupture of membranes.