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甲磺酸多沙唑嗪的合成

Synthesis of doxazosin mesylate
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摘要 甲磺酸多沙唑嗪（doxazosin mesylate,Ⅰ）的化学名为1-（4-氨基-6,7-二甲氧基-2-喹唑啉基）-4-（1,4-苯骈二恶烷-2-甲酰基）哌嗪甲磺酸盐,是一种新型的高选择性α1受体阻滞剂[1],半衰期长,且有明显的降压和降脂作用,同时对单纯性前列腺增生引起的排尿困难具有良好的作用。目前已成为国内外治疗轻中度高血压的一线药物[2,3,4]。 Doxazosin Mesylate was synthesized from catechol and 2,3-dibromo-propanoic acid ethyl ester by cyclization,piperazidintion,condensation,and salification with the yield of 80.2%.The reaction conditions was mild and suitable for industrialization.
作者 崔运启 徐成
机构地区 黄淮学院化学化工系
出处 《化学研究与应用》 CAS CSCD 北大核心 2011年第1期122-124,共3页 Chemical Research and Application
基金 河南省科技发展计划资助项目(092102310208)
关键词 甲磺酸多沙唑嗪 邻苯二酚 2.3-二溴丙酸乙酯 合成 doxazosin mesylate catechol 2 3-dibromo-propanoic acid ethyl ester synthesis
分类号 TQ463 [化学工程—制药化工]
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  • 1王功霞,孙清,孙玲,崔新强,黄庆云.甲磺酸多沙唑嗪合成工艺研究[J].齐鲁药事,2006,25(1):45-47. 被引量：6
  • 2Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial Collaborative Research Group. Diuretic versus alpha-blocker as first-step antihypertensive therapy: final results from the antihypertensive and lipid-Lowering treatment to prevent heart attack Trial (ALLHAT)[J]. Hypertension,2003,42(3):2392-46.
  • 3Wilson TA,Foxall TL,Nicolosi RJ,et al. Doxazosin,an alpha-1 antagonist prevents further progression of the advanced atherosclerotic lesion in hypercholesterolemic hamsters[J]. Metabolism,2003,52(10):1240-1245.
  • 4Kinoshita M,Shimazu N,Fujita M,et al. Doxazosin,an alpha1-adrenergic antihypertensive agent,decreases serum oxidized LDL[J].Am J Hypertens,2001,14(3):267-270.
  • 5Brude IR,Drevon CA,Viken K,et al.Doxazosin treatment and peroxidation of low-density lipoprotein among male hypertensive subjects: in vitro and ex vivo studies[J]. Biochem Pharmacol,1999,58(1):183-191.
  • 6Tamasawa N,Matsui J,Ogawa Y,et al.Effect of doxazosin on the size of LDL particle in the type 2 diabetic patients with hypertension[J]. J Diabetes Complications,2000,14(3):135-139.
  • 7Hirano T,Yoshino G,Kashiwazaki K,et al. Doxazosin reduces prevalence of small dense low density lipoprotein and remnan-like particle cholesterol levels in nondiabetic and diabetic hypertensive patients[J]. Am J Hypertens,2001 ,14(9/1):908-913.
  • 8Lopez Farre A,Rodriguez Feo JA,Garcia-Colis E,et al.Reduction of the soluble cyclic GMP vasorelaxing system in the vascular wall of stroke-prone spontaneously hypertensive rats: effect of the alpha1-receptor blocker doxazosin[J]. J Hypertens,2002,20(3):371-373.
  • 9Courtney CH,McCance DR,Atkinson AB,et al.Effect of the alpha-adrenergic blocker,doxazosin,on endothelial function and insulin action[J]. Metabolism,2003,52(9):1147-1152.
  • 10Komai N,Ohishi M,Moriguchi A,et al.Low-dose doxazosin improved aortic stiffness and endothelial dysfunction as measured by noninvasive evaluation[J]. Hypertens Res,2002,25(1):5-10.

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化学研究与应用
2011年 第1期

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