镇江农村肿瘤高发的病因学研究

Etiologic Study of High Incidence of Cancer in Rural Area in Zhenjiang

目的探讨农村肿瘤高发的病因,为采取预防措施提供依据。方法于2008-04/2009-12,选择肿瘤高发的1个洲2个村为观察区,选择环境相似的1个洲2个村为对照区,对比分析两区居民的肿瘤发生情况和相关影响因素。结果研究区肿瘤标化发病率497.64/10万,显著高于对照区肿瘤标化发病率187.42/10万(χ2=63.51,P<0.01),观察区和对照区前4位均为消化道肿瘤。肿瘤危险因素相对危险度OR值依次为:饮用水>吃腌菜>家族史>常生气,13.712,8.235,4.185,P<0.01,经常生气相对危险度OR=2.731,P<0.05。OR值显示饮用水是影响肿瘤发生的主要危险因素。结论镇江地区农村肿瘤高发主要与饮用水相关,饮用水有机污染可能是镇江农村肿瘤高发的主要危险因素。

Objective To explore the cause of high incidence of cancer in rural area in Zhenjiang and provide evidence for the disease prevention and control.Methods From April 2008 to December 2009,1 islet and 2 villages with high incidence of cancers were selected as observation area and 1 islet and 2 villages with similar environment were selected as control area.The incidence of cancer and related factors in two area were compared.Results The standardized incidence rate of cancer in observation area was higher than that in control area,（χ2 =63.51,P0.01）.The first four cancers were digestive tract tumors in the two areas.The relative risk（OR） value of risk factors for cancer were as follow： 13.712 for drinking water,8.235 for eating of pickles,4.185 for family history,and 2.731 for frequent angry（P0.05）.Drinking water was main risk factor for high incidence of cancer in rural area in Zhenjiang.Conclusion The high incidence of cancer in rural area in Zhenjiang might be associated with drinking water.The organic pollution of drinking water in rural area in Zhenjiang was the main cause of high incidence of cancer.