神经生长因子对甲低功大鼠脑胆碱乙酰转移酶活性的影响

NGF'S INFLUFNCE ON BRAIN CHAT ACTIVITY OF HYPOTHYROID RATS

实验的目的是为了探讨神经生长因子（ＮＧＦ）对甲低功大鼠胆碱乙酰转移酶（ＣＨＡＴ）活性的影响。用１％ＮａＣｌＯ４诱发大鼠甲状腺功能低下，侧脑室注射ＮＧＦ，观察脑ＣＨＡＴ活性变化。结果表明：甲低功大鼠脑ＣＨＡＴ活性降低（与对照组相比Ｐ＜０．０１），注射ＮＧＦ后，脑ＣＨＡＴ活性升高，与实验组有非常显著差别（Ｐ＜０．０１），但仍比对照组低（Ｐ＜０．０５），说明ＮＧＦ能恢复脑ＣＨＡＴ活性。

The purpose of this study was to find out NGFs influence on brain CHAT activity of hypothyroid rats.The experimental hypothyroid rats were induced with 1%NaClO 4.10 NGF was injected into the side vitricles of the rats brain. The results showed that the brain CHAT activity decreased significantly in the hypothyroid rats.( P <0.01),After the injection of NGF,the brain CHAT activity increased,but was still different form controls ( P <0.05),so NGF could lessen the damage of central cholinergic neurons resulted from hypothyroidism.