CAPE及其衍生物的合成和构效关系研究进展

Research Progress on Synthesis and Structure-activity Relationship of CAPE and its Derivatives

咖啡酸苯乙酯(CAPE)是蜂胶的一种主要活性成分,具有抗肿瘤、抗氧化、抗炎和免疫调节等多方面的药理作用。本文主要从CAPE的合成方法,CAPE构效关系,CAPE及其衍生物的构效关系进行了阐述,构效关系的总结对CAPE的结构修饰提供一定的参考作用。

Caffeic acid phenethyl ester was an active component of honeybee propoils,and possesses many pharmacology activities such as anticancer,antioxidative activity,anti-inflammatory and immunoregulatory activity.The methods of synthesis of CAPE,the structure-activity relationship of CAPE,the structure-activity relationship of CAPE and its derivatives were reviewed,and the summary of the structure-activity relationship of CAPE was a good guide for the modification of it.