高未结合胆红素血症新生儿血清肌酸激酶同工酶的测定及意义

Determination and significance of serum CK BB in newborns with hyperbilirubinemia

目的 探讨肌酸激酶同工酶（ Ｃ Ｋ Ｂ Ｂ） 作为诊断新生儿高未结合胆红素血症合并脑细胞损害的应用价值。方法 采新生儿外周血，连续观察３０ 例高未结合胆红素血症新生儿和５９ 例正常新生儿血清中 Ｃ Ｋ Ｂ Ｂ 水平。结果 高未结合胆红素血症新生儿血清中 Ｃ Ｋ Ｂ Ｂ 明显高于正常对照组，是正常新生儿的２６ 倍， Ｐ＜ ０ ．００１ ， Ｃ Ｋ Ｍ Ｂ 组亦明显高于正常组，但其幅度低于 Ｃ Ｋ Ｂ Ｂ 组， Ｃ Ｋ Ｍ Ｍ 组明显低于 Ｃ Ｋ Ｂ Ｂ 组。但高未结合胆红素血症患儿血清中 Ｃ Ｋ Ｂ Ｂ水平与总胆红素相关性差，ｒ＝ ０ ．２２２ ， Ｐ＝ ０ ．０５ 。结论 新生儿血清 Ｃ Ｋ Ｂ Ｂ 增高与高未结合胆红素血症造成的脑细胞损害有关， Ｃ Ｋ Ｂ Ｂ 可作为临床监测高未结合胆红素血症新生儿胆红素脑病的一个筛选指标，值得临床推广。

Objective To determine the predictive value of increased CK BB on neural cell injury in newborns with hyperbilirubinemia.Methods The serum levels of both indirect bilirubin and CK isoenzyme were determined in 30 consecutive neonates suffering from hyperbilirubinemia and 59 normal subjects by a peripheral blood sampling method. Results CK BB level was significantly increased in newborns with hyperbilirubinemia than those without ( P <0.001).Conclusion The increased serum level of CK BB is associated with neural cell injury in newborns with hyperbilirubinemia. It may be used as a screening index of bilirubinic encephalopathy in clinics.