徐州地区部分人群庚型肝炎病毒感染的检测及分析

INVESTIGATION ON INFECTION WITH HEPATITIS G VIRUS AMONG DIFFERENT POPULATIONS IN XUZHOU

目的了解徐州地区部分人群中庚型肝炎病毒（ＨＧＶ）感染状况。方法以逆转录套式聚合酶链反应（ＲＴ－ｎｅｓｔｅｄＰＣＲ）对血清ＨＧＶＲＮＡ进行检测。结果ＨＧＶＲＮＡ阳性率在血液透析患者及丙型肝炎病人中分别为５．５％（１１／３１）、１９．０％（１９／１００），显著高于自然人群１．３％（１／８０）及职业献血员５．０％（２／４０）。乙型肝炎及非甲－非戊型肝炎中ＨＧＶＲＮＡ阳性率分别为７．９％（５／６３）和８．６％（３／３５）。７０．７％的ＨＧＶＲＮＡ阳性患者既往有输血（血制品）史。结论徐州地区人群中ＨＧＶ感染较为广泛，其中血液透析患者和丙型肝炎病人中感染率较高。输血是徐州地区ＨＧＶ感染传播的主要途径。

Objective To survey the prevalence of hepatitis G virus(HGV) among different groups of people in Xuzhou.Methods A reverse transcription polymerase chain reaction assay with nested primers(RT-nested PCR)was established to detect serum HGV RNA.HZResults The positive rates of HGV RNA in patients on haemodialysis and those with hepatitis C were 35.5%(11/31)and 19.0%(19/100)respectively , which were considerably higher than that in natural people(1.3%,1/80)and in the paid donors(5.0%,2/40).However, the rates in patients with hepatitis B and with non-A-E hepatitis were 7.9%(5/63) and 8.6%(3/35) respectively.70.7%(29/41) of those infected with HCV had experienced blood transfusion previously.Conclusion In Xuzhou,HGV infection was rather common, especially in patients on haemodialysis and in patients with hepatitis C,and the infection of HGV was mainly brought about through blood transfusion.