66例血液病患者血小板输注效果与HLA关联的研究

The relationship between the effects of platelet transfusions and HLA in 66 cases of hematology malignance

目的 探讨血液病患者血小板输注的治疗效果与人类组织相容性系统 (HLA)之间的相关性。方法 采用淋巴细胞毒试验 (lymphocytecytotoxicitytest,LCT)和HLA -Ⅰ类分型 ,研究了 66例接受血小板输注的住院病人。血小板校正增加值 (correctedcountincrement,CCI)与LCT的关系。结果 血小板输注无效与LCT阳性率、LCT强度之间呈强关联 (P均 <0 0 1)。结论 研究提示 ,LCT阳性是造成病人血小板输注无效的主要的免疫性因素。输注前检测LCT可预测病人输注效果。

Objective To explore the relationship between the therapeutic effects of platelet transfusion and human histocompatibility antigen system (HLA). Methods The relationship between the corrected count increment (CCI) of platelet with lymphocytotoxicity test (LCT) were studied by using lymphocytotoxicity test and human histocompatibility antigen system-Ⅰ subtype (HLA-Ⅰ) in 66 cases of hospitalized patients who were treated with platelet transfusion. Results Ineffective platelet transfusion was strongly related to LCT positive and LCT intensity ( P <0 01). Conclusion It is suggested that LCT positive is mainly immune factor for ineffective platelet transfusion. Effects of transfusion may be predicted if LCT is measured before transfusion. Effects of platelet transfusion may be improved by using the HLA-matched platelet.