不同剂量奥美拉唑对十二指肠球部溃疡胃内pH的影响

Effect of different dosage of omeprazole and cemitidine on intragastric pH of duodenal ulcer patients

目的 探讨不同剂量的奥美拉唑及西米替丁对十二指肠球部溃疡 (DU)病人胃内pH的影响。方法 采用随机对照的临床研究方法。 4 0例DU病人随机分为 5组 ,每组 8人 ,分别接受①每天 1次静脉注射160 0mg西米替丁 ;②每天 1次静脉注射 4 0mg奥美拉唑 ;③每 12h 1次静脉注射 4 0mg奥美拉唑共 2 4h;④首剂 4 0mg奥美拉唑静脉注射 ,然后以 8mg/h的滴速持续滴注 2 4h ;⑤首剂 4 0mg奥美拉唑静脉注射 ,然后以 4mg/h的滴速持续滴注 2 4h。在用药期间连续 2 4h监测其胃内pH值。结果 后 4组用法均能迅速提高病人的胃内pH值至 6 0 ,其平均胃内pH值分别为 :5 8± 1 3 ,6 91± 0 65 ,6 84± 0 4 5 ,6 81± 0 3 6;pH≥ 6 0时间占整个用药全程的百分比分别为 3 5 8% ,83 3 % ,84 5 % ,85 6% ;而西米替丁则需较长时间方能提高胃内pH值至 6 0 ,其平均胃pH值为 5 4± 1 6,pH≥ 6 0的时间占整个用药全程的 3 0 6%。结论 奥美拉唑能快速提高胃内pH值至 6 0 ,但每天 2次静脉注射 4

Objective To study the effect of different dosage of omeprazole and ranitidine on intragastric pH of duodenal ulcer(DU) patients. Methods 40 patients with DU were divided into 5 groups randomly, each group contained 8 patients: they were assigned to receive ①cemitidine 1 600 mg intravenous injection once daily, ②omeprazole 40 mg intravenous injection once daily, ③omeprazole 40 mg intravenous injection every 12 hours, ④omeprazole 8mg/h after a bolus of 40 mg for 24 hours, ⑤omeprazole 4mg/h after a bolus of 40mg for 24 hours. All the patients were measured intragastric pH during the treatment. Results Four omeprazole groups could rapidly elevate intragastric pH to 6.0, the mean intragastric pH of four groups were 5.8±1 3, 6 91±0 65, 6 84±0 45, 6 81±0 36; the percentage of time spent higher than a pH of 6 0 were 35 8%, 83 3%, 84 5%,85 6%;while the cemitidine, the mean intragastric pH was 5 4±1 6, the percentage of time spent higher than a pH of 6 0 were 30 6% Conclusion Omeprazole can rapidly elevate intragastric pH in patients with duodenal ulcer, omeprazole 40mg intravenous injection every 12 hours and primed infusion after a bolus produced consistently high intragastric pH.