利多卡因、安定治疗心肺疾病患者癫痫状态

Lidocaine and valium in treatment of epilepsy in patients with heart and lung diseases

目的：探讨心肺疾病患者癫痫大发作持续状态（癫痫状态）时抗癫痫药物的疗效和安全性。方法：将１６例心肺患者癫痫状态随机分为利多卡因治疗组和安定对照组，治疗组静脉注射利多卡因１００ｍｇ，对照组静脉注射安定１０ｍｇ。结果：治疗组８例，显效４例，有效２例，无效２例；对照组８例，显效５例，有效１例，无效２例；两组疗效差异无显著性（Ｐ＞０．０５）。利多卡因组无明显不良反应，安定组２例出现呼吸抑制而终止治疗。结论：安定用于心肺患者抗癫痫疗效虽好，但易出现呼吸抑制，选用须慎重；而利多卡因则因安全性高，疗效与安定相同，值得重视。

Objective:To study the therapeutic efficacy and safety of antiepileptic drugs on grand mal patients with heart and lung diseases.Methods:Sixteen cases were divided into 2 groups:the treatment group and the control group.The former group was treated with lidocaine and the latter with valium.Results:The cases obviously improved,improved and not improved in treatment group( n =8) were 4,2,2 and in control group( n =8),were 5,1 and 2 respectively.There was no significant differences between the two groups( P >0.05),no obvious untoward reactions were observed in the former group,but some respiratory inhibition was seen in the latter.Conclusions:The therapeutic efficacy of valium is good in treatment of grand mad,but respiratory inhibition is easily to occur,so should be used with caution.Lidocaine has the same efficacy and is more safe.