乳酸菌对高脂小鼠降胆固醇作用的研究

Cholesterol-lowering effect of lactic acid bacteria in mice with hyperlipidemia

目的探讨乳酸菌对高脂小鼠降胆固醇的作用。方法对昆明小鼠饲喂高脂饲料14 d建立高脂小鼠模型,确定模型建立成功后用1株经体外实验证实具有降胆固醇效果的乳酸菌对小鼠灌胃,测定小鼠经灌胃14、28 d的脏器指数、血清胆固醇含量和肝脏胆固醇含量。结果灌胃组小鼠脏器指数明显低于高脂组小鼠,且对于血清和肝脏胆固醇含量具有明显的降低作用。结论该菌株具有降低血清胆固醇,抑制肝脏胆固醇堆积的功能,为将来利用该菌株制作出降胆固醇功能的食品或药品提供实验基础。

Objective To explore the cholesterol-lowering effect of lactic acid bacteria in mice with hyperlipidemia.Method Mouse models of hypelipidemia were established by feeding kunming mice with high fat diet for 14 days.The models were then gavaged with a strain of lactic acid bacteria which was proved to have cholesterol-lowering effect in vitro.The organ indice levels of serum cholesterol and liver cholesterol of the mice were determinod at days 14 and 28.Result The organ indice of the mice in Gavage group were significantly lower than those in Control group,so were the levels of serum and liver cholesterol.Conclusion The strain may have an effect of lowering serum cholesterol and inhibiting the accumulation of hepatic cholesterol,which provides an experimental basis for future use of the strain to produce cholesterol-lowering functional food or pharmaceutical.