摘要
为了研究干扰素对成纤维细胞的作用，应用了光镜和电镜的方法，观察了创面应用干扰素后对肉芽组织形成的影响。结果显示，创面局部应用干扰素后，光镜下可见新生肉芽组织中的成纤维细胞受到抑制，电镜观察成纤维细胞内合成蛋白质和多糖的细胞器减少。并且应用干扰素后，创面面积较对照组明显缩小（Ｐ＜００５）。结果提示，干扰素在创伤修复中可抑制肉芽组织中成纤维细胞的生长，对瘢痕形成及其异常增生有重要的意义。
In this study,we applied the method of LM and EM to observe the effects of regulation of IFN to fibroblasts on wounded rats.We found that IFN could restrain the growth of fibroblasts on local wounded granulation tissue.And cell organelles of synthetic protein and polysaccaride reduced through observation by EM.The wound area in experiment group was much smaller than that in control group rats ( P <0 05).These results indicated that IFN could restrain the growth of fibroblasts on granulation tissue in wound healing.It was significant to forming scar and abnormal hyperplasia.
