肿瘤内注射^(32)P和^(90)Y-玻璃微球后放射性剂量与生物效应的关系

The relationship between different doses and effect of 32P GTMS and 90Y GTMS in cancer radiotherapy

目的： 了解小鼠肿瘤内直接注射不同剂量３２ Ｐ玻璃微球（３２ Ｐ－ Ｇ Ｔ Ｍ Ｓ） 和９０ Ｙ－ 玻璃微球（９０ Ｙ－ Ｇ Ｔ Ｍ Ｓ） 后，不同时间肿瘤组织的生物效应。材料与方法：采用昆明鼠作为实验动物，腋部皮下接种 Ｓ１８０ 肿瘤细胞，７～１０ 天后在注射部位长出实体瘤块。将每３６ 只带瘤鼠分成三个剂量组，分别向各组鼠瘤块中心注射不同剂量（１ ｍ Ｃｉ，２ｍ Ｃｉ，４ ｍ Ｃｉ） 的３２ Ｐ－ 玻璃微球或９０ Ｙ－ 玻璃微球碘油悬浮液５０ μ１，在注射后不同时间（７ 天，１４ 天，２１ 天，２８ 天） 分批杀死各剂量组小鼠，取出瘤块， 观察瘤体大小及病理变化。结果：３２ Ｐ 和９０ Ｙ－ 玻璃微球具有明显的肿瘤抑制和杀伤作用，它的有效杀伤半径分别约为３ ．５ ｍ ｍ ～４ ｍ ｍ 和５ ｍ ｍ 。结论：３２ Ｐ和９０ Ｙ－ 玻璃微球对肿瘤的有效杀伤半径不随放射性剂量的增加而增大。

Objective:To clarify the biological effect after intratumoral injection of different doses of 32P GTMS or 90Y GTMS. Methods:Seventy two Kunming mice were inoculated subcutaneously with S180 tumor cells.After 7 10 days,The solid tumors grew in mice at the injection sites. Each 36 mice were divided into 3 groups. The 32P GTMS or 90Y GTMS was injected into the tumor center of the test groups with different doses(1 mCi,2 mCi,4 mCi).On the 7th,14th,21th,and 28th days after the injection,72 mice were killed for the tumor size measurement and pathological examination.Results:Significant tumor regression and cell killing effects were observed for both of 32P GTMS and 90Y GTMS.The largest killing radius of 32P GTMS was 3.5～4 mm, and that of 90Y GTMS was 5 mm.Conclusion:The largest killing did not increase with the increase of injected doses.