基于皮肤仿体的甘油光透明效果研究

Optical Clearing Effects Caused by Glycerol Based on Tissue-Simulating Phantoms

为了实现对甘油光透明效果的定量描述,引入组织仿体模拟皮肤的光学参数,分别利用双积分球系统及近红外光谱仪对含有不同浓度甘油的皮肤仿体的光学特性进行测量,研究甘油浓度变化对皮肤仿体光透明效果的影响。结果表明,在632.8nm处随甘油浓度的增加皮肤仿体的散射系数降低,光穿透深度也得到提高,最大能提高48.76%;同时,皮肤仿体在近红外波段的透射能量也随着甘油浓度的增加而增大,即总衰减系数降低,从而表明利用皮肤仿体可描述甘油引起的光透明效果与甘油浓度变化的定量关系。

In order to describe optical clearing effects of glycerol quantitatively,tissue-simulating phantoms whose optical properties are identical with that of human skin tissue are introduced.The optical clearing effects of tissue-simulating phantoms with different concentrations of glycerol have been studied by using double integrating spheres system and Fourier transform-infrared （FT-IR） spectrophotometer.The results show that the scattering coefficients of skin phantoms decrease with the rising glycerol concentration at the wavelength of 632.8 nm,and the light penetration depth increases and the maximum percentage attains to 48.76%.Meanwhile,with the increase of glycerol concentration,the transmittance of skin phantoms increases as well,which equales the reduction of total attenuation coefficients.Therefore,the correlation can be obtained quantitatively between the optical clearing effects induced by glycerol and its concentration in tissue-simulating phantoms.