三甲基硅化腈在有机合成中的应用

Advances in the Application of Trimethylsilyl Cyanide for Organic Synthesis

三甲基硅化腈是一种常用的有机合成试剂.对近年来三甲基硅化腈在有机合成中的应用进行了简要的总结和概述,重点介绍了三甲基硅化腈作为强的亲核试剂广泛用于环氮和环氧化合物的开环反应、亚胺和醛酮类化合物的加成、胺与醛或酮参与的多组分反应、偶联反应以及对炔和具有较高活性的碳碳双键的氰化加成等反应。

Trimethylsilyl cyanide is a widely used organic reagent. An overview of recent advances in applications of trimethylsilyl cyanide as a nucleophile in organic synthesis are presented herein. The review is organized in the order of the following reaction types： the ring-opening reaction of aziridine and epoxide, nucleophilic addition to imine and aldehyde or ketone, multicomponent reaction involved amine and aldehyde or ketone, coupling reaction, hydrocyanation to alkyne or active alkenes and so on.