摘要
在微波无溶剂无催化条件下,以取代吡唑甲醛、芳胺和亚磷酸二乙酯为原料合成了一系列新型含吡唑基的α-氨基膦酸酯类衍生物,其结构经1H NMR,13C NMR,MS和31P NMR测试技术进行了表征.初步生测结果表明,部分化合物表现出不同程度的抗菌活性。
A series of novel a-aminophosphonate derivatives containing substituted pyrazole were synthesized with substituted pyrazolyl aldehyde, arylamine and diethylphosphone under microwave-assisted without using any catalysts and solvent. And the structures of the compounds were confirmed by ^1H NMR, ^13C NMR, ^31p NMR and MS techniques. Preliminary bioassay indicated that some of them showed good fungicidal activities.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2011年第1期63-67,共5页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.20872029)
河南省高校科技创新团队支持计划(No.2008IRTSTHN002)资助项目
关键词
吡唑
氨基膦酸酯
微波无溶剂合成
抗菌活性
pyrazole
aminophosphonate
microwave-assisted solvent-free synthesis
biological activity
