还原型谷胱甘肽联合异甘草酸镁治疗酒精性肝病的对照研究

Therapeutic Efficacy of Reduced Glutathione Combined with Magnesium Isoglycyrrhizinate for Alcoholic Liver Disease

目的:观察还原型谷胱甘肽片联合异甘草酸镁注射液静脉滴注治疗酒精性肝病的临床疗效。方法:60例酒精性肝病患者均戒酒,随机分为治疗组(30例)和对照组(30例)。治疗组给予还原型谷胱甘肽片联合异甘草酸镁注射液静脉滴注,对照组仅给予异甘草酸镁注射液静脉滴注,疗程均为4周。结果:2组患者治疗后临床症状、体征、实验室检查及彩超检查结果均有一定程度的改善,且治疗组疗效优于对照组,2组比较差异有统计学意义(P<0.05)。结论:还原型谷胱甘肽片联合异甘草酸镁注射液治疗酒精性肝病疗效好,未见明显不良反应。

OBJECTIVE： To observe the clinical efficacy of oral dose of reduced glutathione combined with dripping injection of magnesium isoglycyrrhizinate for alcoholic liver disease. METHODS ： A total of 60 patients with alcoholic liver disease who had been abstained from wine were randomly assigned to treatment group and control group （30 cases）. Treatment group was given oral dose of reduced glutathione and intravenous dripping injection of magnesium isoglycyrrhizinate for 4 weeks. Control group was treated with intravenous dripping injection of magnesium isoglycyrrhizinate alone for 4 weeks. RESULTS： Clinical symptoms and signs, laboratory examination and B-ultrosound results were all improved in both groups, especially in the trial group. Significant differences were noted between the 2 groups （P〈0.05）. CONCLUSION： Oral dose of reduced glutathione combined with intrave- nous dripping injection of magnesium isoglycyrrhizinate is safe and effective for alcoholic liver disease without obvious adverse drug reaction.