复方苦参注射液雾化吸入联合NP方案治疗晚期非小细胞肺癌的疗效观察

Efficacy Observation of Aerosol Inhalation of Compound Sophora flavescens Injection Combined with NP Regimen in the Treatment of Advanced Non-small Cell Lung Cancer

目的:观察复方苦参注射液雾化吸入联合NP方案治疗晚期非小细胞肺癌的临床疗效。方法:将病理学或者细胞学检查确诊的377例晚期非小细胞肺癌患者随机分成试验组和对照组。试验组188例,采用复方苦参注射液雾化吸入联合NP方案全身化疗;对照组189例,单纯采用NP方案全身化疗。2组化疗均21d为1个周期,至少4个周期,在第2周期结束时评价疗效。结果:试验组和对照组的有效率分别为52.5%和41.4%(P<0.05)。试验组胃肠道反应和骨髓抑制较对照组减轻,差异有统计学意义(P<0.05);试验组和对照组患者中位生存期分别为9.56个月和7.60个月(P<0.05),化疗后生存质量KPS评分试验组明显高于对照组(P<0.05)。结论:复方苦参注射液雾化吸入联合NP方案治疗晚期非小细胞肺癌疗效好,患者不良反应轻,具有提高中位生存期,改善患者生存质量的作用。

OBJECTIVE： To observe clinical efficacy of aerosol inhalation of Compound Sophora flavescens injection combined with NP regimen in the treatment of advanced non-small cell lung cancer （NSCLC）. METHODS： 377 patients diagnosed as advanced NSCLC by pathology or cytology were randomly divided into experimental group and control group. 188 patients in exper- imental group were treated with aerosol inhalation of Compound S. flavescens injection combined with NP regimen. 189 patients in control group received NP regimen chemotherapy alone. Both regimens were repeated every 3 weeks at least 4 cycles, and the thera- peutic efficacy was evaluated at the end of the 2rd cycle. RESULTS ： The effective rates of experimental group and control group were 52.5% and 41.4% （P〈0.05）. The gastrointestinal reactions and myelosuppression in experimental group were alleviated, compared with control group. There was significant difference between 2 groups （P〈0.05）. The median survival time was 9.56 months in experimental group while 7.60 months in control group （P〈0.05）, KPS score after chemotherapy in experimental group was significantly higher than in control group （P〈0.05）. CONCLUSION： Aerosol inhalation of Compound S. flavescens injection combined with NP regimen shows sound therapeutic effect on advanced NSCLC, reduces adverse drug reactions, increases median survival time and improves the quality of life.