赛红霉素的合成工艺

Synthesis process of Cethromycin

目的改进赛红霉素的合成工艺。方法以红霉素A为原料,经肟化、酯化、烃基化、脱保护、脱肟、环氨甲酸酯化、酸水解、氧化和去保护等10步反应合成目标化合物。结果和结论改进后的方法操作简便,成本降低。

OBJECTIVE To improve the synthetic process of Cethromycin（ABT-773）.METHODS The target compound was synthesized through oximation,esterification,alkylation,deprotection,deoximation,cyclocarbamation,acid hydrolysis,oxidation and deprotection from erythromycin A.RESULTS and CONCLUSION Cethromycin was synthesized successfully.Modified method has the advantages of simple manipulation,lower cost.