幽门螺杆菌耐药现状及临床治疗对策

Present situation of drug resistance and the countermeasure of clinical treatment of Helicobacter pylori

随着治疗根除幽门螺杆菌(Hp)抗生素的广泛使用,中国2006～2010年间幽门螺杆菌(Hp)对甲硝唑、克拉霉素、阿莫西林的耐药率逐年上升。治疗上强调地区化、个体化、序贯疗法和四联方案延长疗程法等,应用呋喃唑酮、四环素和喹诺酮类(如左氧氟沙星和莫西沙星)抗生素,采取时间间隔3～6个月的治疗策略能提高幽门螺杆菌的根除率。

As the widespread use of antibiotics eradicating Helicobacter pylori（ Hp）, the drug resistance rate of Helicobacter pylori （Hp） to metronidazole, clarithromycin and amoxiciUin goes up year by year during 2006 to 2010 in China. It should be necessarry to stress the regional disparity and individual treatment in the area where there emerges drug resistance of Helicobacter pylori. And it should be necessarry to adopt various treatment strategies to improve the elimination rate of Helicobacter pylori. The treatment strategies include sequential treatment, four regimens extended regimen, antibiotics therapy using furazolidone, tetracyline and fluoroquinolone （such as levofloxacin and moxifloxacin） and interval 3 - 6 months therapy.