Toll样受体与细胞迁移

Toll-like receptors and cells migration

敏感性侵袭病原体侵入机体，生殖系编码模式识别受体识别病原体，由此启动先天免疫系统。Toll样受体家族（toll-like receptors，TLR）是在免疫系统特异性识别微生物病原体抗原中发挥重要调控作用的受体家族。TLR表达于许多的免疫和非免疫细胞，参与多种细胞迁移，与细胞的迁移性运动密切相关。活化TLR诱导产生一系列的炎症介质包括细胞因子、趋化因子等从而产生强有力的生物学效应。TLR最突出的生物学功能一方面促进细胞因子或趋化因子的合成与释放，引发炎症反应或细胞效应，另一方面是促进抗原递呈细胞的成熟，从而诱导机体的获得性免疫反应，因而是机体介导天然免疫转向获得性免疫的桥梁。

The invasion of sensitive pathogens invade the body, and reproductive system encoded pattern recognition receptors recognize pathogens, thus start the innate immune system. Toll-like receptor （TLR） plays an important role in the immune system recognition of microbial pathogens thus is a regulating antigen receptor family. TI.R are expressed on many immune and non immune ceils while participate in a variety of cell migration, so they are closely related to movement and migration of cells. Activation of TLR induce a series of inflammatory mediators,including cytokines, chemokines and so on, and result in strong biological effects. The most prominent biological function of TLR is on the one hand, they enhance the synthesis and release of cytokine and chemokine that trigger inflammation and cell effect, on the other hand, they promote the mature of antigen presenting cells that induce the acquired immune response. So TLR are the bridge of innate immunity and acquired immunity.