肿瘤抑制基因Rb与细胞周期调控研究新进展

Recent Progress in the Correlation Between Tumor Suppressor Gene Rb and Checkpoint Control in Cell Cycle.

Ｒｂ 与人类多种肿瘤发生关系密切， 是一种重要的肿瘤抑制基因． Ｒｂ 蛋白参与细胞周期调控， 与ｐ１６、ＣＤＫ４／６、ｃｙｃｌｉｎＤ１ 等形成复杂的反馈调节网络， 在Ｇ１／Ｓ关卡调控中处于中心环节， 决定着细胞周期的进程．Ｒｂ 又是核内信号与胞外信号相互作用的界面， 受到胞内外多种因素的调控， 使Ｒｂ 功能与细胞生长、分化状态相适应．

Rb correlates with tumorigenesis closely, and is an important tumor suppressor gene. Rb protein forms a complicated feedback regulation pathway combined with p16, CDK4/6, cyclinD1 to control cell cycle. Rb is a central step in G1/S checkpoint control to determine cell cycle progression . Rb protein acts as an interface of interaction between nuclear and extracellular signals and is controlled by many extracellular factors which control cell growth and differentiation.