转化生长因子β受体的研究进展

Study of Tranforming Growth Factor β Receptor.

转化生长因子β受体为胞膜蛋白， 存在５ 种形态， Ⅲ型受体主要是调节受体与配体之间的亲和力及Ⅱ型受体的膜上表达． 功能性受体则主要为Ⅰ、Ⅱ型． Ⅰ、Ⅱ型受体在介导信号传递时相互配合， 又存在分工不同：Ⅰ型受体为介导转化生长因子β促细胞外基质合成的信号通道． 而Ⅱ型受体则与细胞的增殖。

Tranforming growth factor β receptor, divided into five types, are membrane protein. The functin of type Ⅲ receptor is regulating the affinity between receptor and ligand as well as the expression of type Ⅱ receptor. Type Ⅰ and type Ⅱ receptor are functional receptors. They cooperate closely while the signal transduction, and on the other hand. They function differently: type Ⅰ receptor acts as the signal pathway by which transforming growth factor β stimulate the increasing synthesis of extracellular matrix ; type Ⅱ receptor has closely relationship to the proliferate and differentiate cells.