慢性心力衰竭患者血清N末端-脑钠肽前体水平检测分析

Analysis of N-terminal Pro-brain Natriuretic Peptide Levels in Patients with Chronic Heart Failure

探讨慢性心力衰竭(CHF)患者血清N末端-脑钠肽前体(NT-proBNP)水平的变化及临床意义。择128例CHF患者为CHF组,20例无器质性心脏病者为对照组。所有受试者均采用NYHA分级法分级诊断心功能,电化学发光双抗体夹心免疫法检测血清NT-proBNP水平,心脏彩色多普勒超声测定左心室射血分数(LVEF)。对比CHF组与对照组的血清NT-proBNP水平,分析CHF患者血清NT-proBNP水平与NYHA心功能级别和LVEF的关系。结果显示:CHF患者血清NT-proBNP水平显著高于对照组(P<0.05),并随NYHA心功能级别增高而升高(P<0.05),随LVEF下降而升高(r=-0.595,P<0.05)。结论:血清NT-proBNP水平能较好地反映失代偿性CHF患者的心功能状态,有助于CHF的诊断和病情评估。

To investigate the changes and its clinical significance of serum N-terminal pro-brain natriuretic peptide（NT-proBNP） levels in patients with chronic heart failure（CHF）,128 patients with decompensated CHF and 20 patients without structural heart disease were selected as CHF and control group.All subjects were evaluated heart function by New York Heart Association（NYHA） class.The serum NT-proBNP levels were assayed by electrochemiluminescence double antibody sandwich immunoassay.Left ventricular ejection fraction（LVEF） was detected by color Doppler ultrasound.The results showed that the NT-proBNP levels in CHF group were significantly higher than that of in the control group（P0.05）.Further,the NT-proBNP levels showed an increased tendency accompanied by the severity of heart failure（P0.05） and lowering of LVEF（r=-0.595,P0.05）.The serum NT-proBNP levels can reflect the state of cardiac function in patients with decompensated DHF,and useful in the diagnosis and severity assessment of CHF.