HER-2、P53、Ki-67、Nm23、ER、PR蛋白在乳腺癌中的表达及临床意义

Expression of HER-2,P53,Ki-67,Nm23,ER and PR Proteins in Breast Cancer and Their Clinical Significance

探讨HER-2、P53、Ki-67、Nm23、ER、PR蛋白在乳腺癌组织中表达的特性,同时分析它们之间的相关性和临床意义。应用SP免疫组织化学法检测73例乳腺癌标本中HER-2、P53、Ki-67、Nm23、ER、PR蛋白的表达,并结合其临床和病理资料进行回顾性分析。HER-2、P53、Ki-67、Nm23、ER、PR在乳腺癌中的阳性表达率依次为47.9%(35/73)、69.9%(51/73)、87.7%(64/73)、84.9%(62/73)、60.3%(44/73)、56.2%(41/73),除HER-2与腋窝淋巴结转移存在明显相关性外,其他五项表达与患者年龄、肿瘤大小、腋窝淋巴结转移和组织学分级无显著相关性,而PR与ER,ER与P53之间存在显著正相关,PR与Ki-67,ER与HER-2之间存在显著负相关。HER-2的表达可以作为乳腺癌预后的检测指标,同时应该结合激素受体、Ki-67、P53的表达综合评定,指导术后治疗。

To investigate the expression characteristic of human epidermal growth factor receptor（HER-2）,P53,Ki-67,Nm23,estrogen receptor（ER） and progesterone receptor（PR） proteins in invasive duct carcinoma of breast,and analyze their correlation and clinical significance,the SP immunohistochemical technique was used to determine HER-2,P53,Ki-67,Nm23,ER,and PR proteins expression in 73 patients with breast cancer.The relationships between the expression of proteins and the clinical and pathological data of patients were retrospectively analyzed.The results showed that the expression rate of HER-2,P53,Ki-67,Nm23,ER,and PR proteins in patients were 47.9%,69.9%,87.7%,84.9%,60.3%,and 56.2% respectively.The expression of six proteins was not significantly correlated with the patient age,the tumor size,the axillary lymph node metastasis,and the history grade（P0.05）,exception of HER-2 with the axillary lymph node metastasis（P0.05）.The expression of PR was significantly positive correlated with ER,ER and P53（P0.05）.The expression of PR was significantly negative correlated with Ki-67,ER and HER-2（P0.05）.HER-2 over-expression is maybe a significant molecular marker for detection of breast cancer,and the combination of HER-2 with hormone receptor,Ki-67 and P53 expressions could be used to evaluate clinical prognosis and select therapeutic options.