实验性肺栓塞溶栓前后IL-1β变化的意义

Study of the changes and clinical significance of Interleukin-1βbefore and after experimental pulmonary thromboembolism in rabbits

目的探讨兔实验性肺栓塞症(PTE)溶栓前后白细胞介素-1β(IL-1β)的变化及其临床意义。方法健康中国大耳白兔30只,按照随机数字法将实验动物分为肺栓塞组、对照组和溶栓组,每组10只。栓塞组和溶栓组自颈静脉注入自体小血凝块建立家兔急性肺栓塞模型,溶栓组从耳静脉注入尿激酶。结果栓塞组兔的肺脏表面凸凹不平,有散在苍白病灶,并可见点片状出血灶,镜下肺动脉血管内可见有注入的血凝块,血管壁炎症细胞浸润及间质出血。栓塞后5天处死的兔子可见栓塞灶内有肉芽组织形成。肺栓塞后IL-1β3、4 h升高;溶栓组2个小时后变化无显著差异。结论 PTE兔3、4 h内IL-1β有不同程度的升高,溶栓后明显降低。

Objective To study the changes and cilinical significance of Interleukin - 1β before and after experimental pulmonary thromboembolism in rabbits. Methods Rabbits pulmonary thromboembolism models by injection of auto - blood clots into femoral vein were used to observe the changes of IL - 1β. Results Petechial and patchy hemorrhehages were observed on the surfaces of emholic lungs. The injected blood clots could be found by microscope, the concentration of IL - 1β in blood were significantcly elevated after embolism, but not significantely elevated after administration of urokiuase. Conclusion IL - 1β in blood vary in the concentration before and after experimential pulmonary thromboembolism and thrombolysis therapy.