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激素敏感性肾病综合征患儿血清白细胞介素-18表达和T细胞亚群变化的意义

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摘要 目的探讨激素敏感型肾病综合征(SSNS)患儿血清白细胞介素-18以及T细胞亚群变化及意义。方法应用流式细胞仪对23例活动期和30例缓解期SSNS分别检测TNF-α、IL-10的水平变化及血清中的白细胞介素-18,分析各临床指标的相关性。结果 SSNS患儿活动期IL-18、TNF-α水平显著高于缓解期及正常儿童,活动期IL-10较缓解期和正常儿童无明显变化。血清IL-18与TNE-α水平呈正相关,与IL-10无明显相关性;缓解期患儿TNF-α、IL-10、IL-18与正常儿童无明显变化。结论 SSNS患儿在活动期外周血T淋巴细胞亚群间比例失调,IL-18促进了TH1免疫应答,是参与SSNS发病的重要介导因子。
作者 乔文兴 王英娟
机构地区 陕西省榆林市第一医院儿科
出处 《齐齐哈尔医学院学报》 2010年第22期3539-3540,共2页 Journal of Qiqihar Medical University
关键词 肾病综合征 儿童 T细胞亚群 白细胞介素-18
分类号 R753.9 [医药卫生—皮肤病学与性病学]
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参考文献8

  • 1Tain YL,Liu CA,Yang KD.Implications of blood soluble and cell surface tumor necrosis factor receptors in childhood nephritic syndrome[J].Pediatr Nephrol,2002,17(11):926-932.
  • 2Okamura H,Tsutsi H,Komatsu T,et al.Cloning of a new cytokine that induces IFN-gamma production by T cells[J].Nature,1995,378(6552):88-91.
  • 3彭彦,王勇,宋方洲,王亚平.IL-18在大肠杆菌中的可溶性表达和纯化[J].重庆医科大学学报,2006,31(4):524-527. 被引量：2
  • 4Ushio S,Namba M,Okura T,et al.Cloning of the cDNA for human INF-γ_inducing factor,expression in Escherichia coli,and studies on the biologic activities of the protein[J].J Immunol,1996,156(11):4274-4279.
  • 5中华医学会中华儿科杂志编辑委员会.小儿肾小球疾病临床分类与肾病综合征的治疗.中华儿科杂志,2001,39(12):710-710.
  • 6Nakanishi K,Yoshimoto T,Tsutsui H,et al.Interleukin 18 regulates both Th1 and Th2 responses[J].Annu Rev Immunol,2001,19:423-74.
  • 7陈珊琳,王彩霞,肖林生.白细胞介素18抗体对小鼠微小病变型阿霉素肾病的治疗作用[J].中华儿科杂志,2007,45(11):869-870. 被引量：2
  • 8Matsumoto K,Kanmatsuse K.Augmented interleukin-18 production by peripheral blood monocytes in patients with minimal_change nephritic syndrome[J].Am J Nephrol,2001,21:20-27.

二级参考文献15

  • 1Okamura H,Tsutsi H,Komatsu T,et al.Cloning of a new cytokine that induces IFN-gamma production by T cells[J].Nature,1995;378-388.
  • 2Tanaka H,Narita M,Teramoto S,et al.Role of interleukin-18 and T-helper type 1 cytokines in the development of Mycoplasma pneumoniae pneumonia in adults[J].Chest,2002; 121 (5):1493-1497.
  • 3Dinarello CA.Interleukin-18,a proinflammatory cytokine[J].Eur Cytokine Netw,2000 ;11 (3):483-486.
  • 4Yamanaka R,Tsuchiya N,Yajima N,et al.Induction of an antitumor immunological response by an intratumoral injection of dendritic cells pulsed with genetically engineered Semliki Forest virus to produce interleukin-18 combined with the systemic administration of interleukin-12[J].J Neurosurg,2003 ;99(4):746-753.
  • 5Okamoto I,Kohno K,Tanimoto T,et al.IL-18 prevents the development of chronic graft-versus-host disease in mice[J].J Immunol,20001; 164(11):6067-6074.
  • 6Papamichail M,Perez SA,Gritzapis AD,et al.Natural killer lymphocytes:biology,development,and function[J].Cancer Immunol Immunother,2004 ;53(3):176-186.
  • 7Schmidt OI,Morganti-Kossmann MC,Heyde CE,et al.Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain:a clinical and experimental study in head-injured patients and in a murine model of closed head injury[J].J Neuroinflammation,2004;28 1 (1):13.
  • 8Araya CE, Wasserfall CH, Brusko TM, et al. A case of unfulfilled expectations, cytokines in idiopathic minimal lesion nephrotic syndrome. Pediatr Nephrol,2006,21:603-610.
  • 9Matsumoto K, Kanmatsuse K. Interleukin-18 and interleukin-12 synergize to stimulate the production of vascular permeability factor by T lymphoeytes in normal subjects and in patients with minimalchange nephrotic syndrome. Nephron,2000,85: 127-133.
  • 10Matsumoto K, Kanmatsuse K. Elevated interleukin-18 levels in the urine of nephrotic patients. Nephron,2001,88 :334-339.

共引文献5

齐齐哈尔医学院学报
2010年 第22期

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