社交焦虑障碍患者表情刺激视觉电位P300研究

A study on visual P300 evoked by facial expression stimulus in social anxiety disorder

目的 探讨社交焦虑障碍（Social Anxiety Disorder,SAD）患者由表情刺激所诱发的视觉电位P300的变化.方法 对30例SAD患者及30例正常对照人群进行自编社会人口学资料表及李伯韦兹社交焦虑量表（LSAS）评估,并进行由悲伤、高兴、惊讶、生气和厌恶5种表情刺激所诱发的视觉P300检测.结果 SAD患者在生气表情诱发的靶P2波幅[（3.73±3.06）μV]及靶P3波幅[（9.43±4.01）μV]高于正常对照组（P＜0.05）,厌恶表情诱发的靶P3波幅[（9.57±4.42）μV]高于正常对照组（P＜0.05）;SAD患者的LSAS评分与生气表情诱发的靶P2波幅呈正相关（P＜0.05）.结论 SAD患者具有异常的由表情刺激诱发的视觉P300变化指标.

Objective To explore the changing indications of visual P300 evoked by facial expression stimulus in social anxiety disorder （SAD）. Methods 30 patients with SAD were consecutively recruited, and matched with 30 normal controls （NC）. They were evaluated by self-designed demographic questionnaire and Liebowitz Social Anxiety Scale （LSAS）, Meanwhile the examination of the visual P300 evoked by five facial expression stimulus included sad, happy, surprise, angry and disgust was administrated to SAD patients and normal controls. Results Compared with NC group, SAD group had higher target P2 amplitudes （ （ 3.73 ± 3.06 ） μV ）and higher target P3 amplitudes（ （ 9.43 ± 4.01 ） μV ） evoked by angry facial expression （P〈 0.05 ） and higher target P3 amplitudes（ （9.57 ±4.42） μV） evoked by disgust facial expression （P〈0.05）. The scores of LSAS in SAD was positively correlated with target P2 amplitudes （P〈0.05）. Conclusion SAD group has abnormal changing indications of visual P300 evoked by facial expression stimulus.