九里香叶黄酮类成分的研究(Ⅰ)

Studies on Flavonoids from Leaves of Murraya panaculata L.(Ⅰ)

目的对九里香(Murraya paniculata L.)叶的黄酮类成分进行分离鉴定。方法体积分数85%乙醇提取,大孔吸附树脂吸附、硅胶和ODS柱色谱法进行分离纯化,根据理化性质和光谱数据鉴定结构。结果分离得到8个化合物,分别鉴定为5,6,7,3,′4′-五甲氧基黄酮(Ⅰ),5,7,8,3,′4′-五甲氧基二氢黄酮(Ⅱ),5,7,3,′4′-四甲氧基黄酮(Ⅲ),5,7,3,′4,′5′-五甲氧基黄酮(Ⅳ),5,6,7,3,′4,′5′-六甲氧基黄酮(Ⅴ),5-羟基-6,7,8,3,′4′-五甲氧基黄酮(Ⅵ),5,3′-二羟基-7,4′-二甲氧基黄酮(Ⅶ),7-羟基-5,3,′4′-三甲氧基黄酮(Ⅷ)。结论除化合物Ⅲ、Ⅳ、Ⅴ外,均为首次从该植物中分离得到。

OBJECTIVE To study the flavonoids from leaves of Murraya panaculata L. METHODS The constituents were iso- lated and purified by column chromatography on silicagel, ODS and macroporous adsorption resin. Compounds were identified by physi- cochemical and spectral data. RESULTS Eight compounds were isolated and identified as 5,6,7,Y,4＇-pentamethoxyflavone （ I ）, 5,7,8,3＇,4 ＇-pentamethoxyflavanonol （II ）, 5,7,3＇, 4＇-tetramethoxyflavone （ III ）, 5,7,3,, 4,, 5 ＇-pentamethoxyflavone （ IV ）, 5,6,7,3＇, 4＇, 5 ＇-hexamethoxyflavone （ V ） ,5-hydroxy-6,7,8,3＇, 4＇-pentamethoxyflavone （ VI ）, 5,3＇-dihydroxy-7,4＇-dimethoxyflavone （ VII ）, 7-hy- droxy-5,Y,4＇-trimethoxyflavone（Ⅷ）. CONCLUSION Except fer the eompound m, IV and V , all the compounds were isolated from Murraya panaculata L. for the first time.