颅脑创伤后强迫症患者血小板5-羟色胺水平的对照研究

A comparative study of platelet serotonin in patients after traumatic brain injury with obsessive compulsive disorder

目的探讨颅脑创伤后强迫疗患者血小饭5-羟色胺（5-HT）水平。方法测定符合诊断标准的27例颅脑创伤后强迫症患者（强迫症组）和27名颅脑创伤后非强迫症患者（对照组）的血小板5-HT水平。结果颅脑创伤后强迫症组血小板5-HT水平[（139±172）μg/L]低于正常人组[（248±215）μg/L]，差异具有显著性（P〈0．05）。结论强迫症患者症状与5-HT浓度变化有相关性；单纯强迫思维者的5-HT浓度与单纯强迫动作患者的差异有显著性。

Objective To explore the role of serotonin（5-HT） in ohsessive compulsive disorder（OCD） and the difference in platelet 5-HT conntent hehveen OCD and healthy controls, the ot）session and the compulsion subgroup. Methods The concentration of serotonin （5-HT） in twenty-seven patients with OCD and twenty-seven patients without OCD were deteeled in the study. Results Platelel serotonin level in patients with OCD （ （ 139 ± 172） μg/L） was lower than that in patients without OCD（ （248 ±215 ） μg/L） ,and the differences were significant （P〈 0.05 ）. Conclusion The present results support the hypothesis that 5-HT hypofunetionality contribute to OCD. And the differences between the nhsession and the compulsion suhgroup in the role of 5-HT are significant.