摘要
目的：探讨血清中肿瘤标记物CEA、CA199、CA125和CA242检测在直肠癌诊断中的意义.方法：应用化学发光法对42例直肠癌患者CEA、CA199、CA125和CA242的水平进行检测,并收集50例健康者四个指标检测结果为对照.结果：直肠癌患者术前四种肿瘤标记物的的水平明显较高,和健康对照组比较,差异均具有统计学意义（P〈0.05）.但是,CA199和CA242两个指标在术后的水平也比正常人高,差异具有统计学意义（P〈0.05）.结论： CEA、CA199、CA125以及CA242四个肿瘤标记物单项检测对直肠癌的敏感性和特异性均较低,联合检测多个标记物能使恶性肿瘤的检出率明显增加.
Objective： To investigate the diagnosis value of the serum tumor markers CEA, CA199, CA125 and CA242 detect：ion in rectal cancer. Methods： CEA, CA199, CA125 and CA242 of 42 patients with rectal cancer were detected using Chemiluminescence, and made 50 healthy test results as control. Results： Levels of four tumor markers in rectal cancer group were higher than the healthy control group （P 〈0.05）. However, CA199 and CA242 levels after operation were still higher than normal （P 〈0.05）. Conelusion： Sensitivity and specificity of inclividual detection of CEA, CA199, CA125 and CA242 in rectal cancer were lower; the joint detection of multiple markers could significantly increase the detection rate of malignant tumors.
