FOLFOX方案治疗晚期胃癌的疗效分析

FOLFOX regimen in the treatment of patients with advanced gastric cancer

目的：观察FOLFOX方案治疗晚期胃癌的疗效及不良反应.方法：奥沙利铂100mg/m2,静滴2h第1天;亚叶酸钙150mg/m2,静滴30分钟第1～5d;氟尿嘧啶500mg/m2,静滴6h,第1-5天,每3-4周重复,治疗2周期进行疗效评价.结果：64例均经病理组织学确诊为胃腺癌,在可评价疗效56例患者中,无CR病例,PR22例、SD16例、PD18例,有效率39.30%,中位生存期11.5月.FOLFOX方案的主要不良反应为：中性粒细胞减少;恶心、呕吐和末梢神经感觉异常,多为Ⅰ-Ⅱ度,Ⅲ度不良反应主要为：恶心、呕吐5例、末梢感觉异常3例.结论：FOLFOX化疗方案治疗晚期胃癌疗效确切,不良反应可耐受.

Objective The aim of this study is to investigate the efficiency and toxicity of FOLFOX regimen in the patients with advanced gastric cancer. Methods Oxaliplatin was given at a dose of 100mg/m2 i. v. 2 hours D1, calcium folinate （CF）100mg/m2 i. v. 1/2 hour D1--DS, 5--fluorouraeil （5--Fu） 500mg/m2 i. v. 6hours D1--DS. Cycles were repeated every 3--4 weeks. Efficiency and toxicity were evaluated every 2 cycles. Results 64 pa- tients were pathologically confirmed as gastric cancer. The therapeutic response was evaluated in 56 patients（none complete response, 22 partial re- sponse, 16 a stable disease and 18 experienced disease progression. ）with response rate 39.30%. The medium overall survival was 11.5 months. All the 56 cases were evaluable for toxicity according to NCI criteria. The major adverse effects were hematological toxicity, grades 1--2 vomiting and neural toxieltles. The patients of grade 3 vomiting and neural toxlclties were 3 and 5, respectively. Conclusion FOLFOX regimen is active and well tolerated in the treatment of patients with advanced gastric cancer.