茶多酚和维生素C联合补充对高尿酸血症伴脂代谢异常者的改善效果研究

EFFECT OF TEA POLYPHENOLS AND VITAMIN C INTERVENTION ON PATIENTS WITH HYPERURICEMIA AND DYSLIPIDEMIA

目的探讨茶多酚(TP)和维生素C(VC)联合补充对高尿酸血症伴脂代谢异常的改善作用及体内抗氧化能力的影响。方法将114名原发性高尿酸血症伴脂代谢异常的男性患者随机分为试验组(TP 300mg/d+VC 250mg/d)及对照组(安慰剂),比较两组干预1年前后血清尿酸、血脂代谢和抗氧化指标的变化。结果 96名患者完成研究(失访率13.1%)。干预后两组血尿酸水平有统计学差异[试验组vs对照组(0.437±0.071)mmol/L vs(0.465±0.059)mmol/L,P=0.037];试验组TC水平较对照组有统计学意义下降[干预组vs对照组(5.32±0.85)mmol/L vs(5.68±0.80)mmol/L,P=0.036]。TG,LDL,HDL及FBG两组干预后无统计学差异。干预后试验组血清MDA较对照组有统计学意义下降[(2.58±1.17 nmmol/ml)vs(3.65±1.8 nmmol/ml),P=0.003],SOD,GSH两组干预结束时无统计学差异。试验组和对照组MDA分别下降65.49%,31.99%;SOD分别升高56.02%,31.61%;GSH分别升高9.51%,3.36%。两组间MDA,SOD有统计学差异(P<0.05),GSH两无统计学差异。干预后试验组CRP较对照组有统计学意义下降[(1.34±1.26 mg/L)vs(2.22±2.03 mg/L),P=0.021]。结论茶多酚和VC的联合补充有助于降低高尿酸血症伴血脂代谢异常者的血尿酸及血脂水平,并改善机体氧化应激状态。

Objective A randomized-placebo double blind trial was performed to study the influence of tea polyphenols（TP） and vitamin C（VC） on patients with hyperuricemia and dyslipidemia.Method One hundred and fourteen subjects with hyperuricemia and dyslipidemia were double-blind randomized to the intervention group（TP 300mg/d and VC 250 mg/d） and placebo group for 1 year.Blood biochemical analysis and physical examination were performed at the baseline and end of the trial.Results Ninety six persons completed the study.After the trial,compared to placebo group,serum uric acid and cholesterol and also MDA decreased significantly in the intervention group（P〈0.05）.There were no significant differences in TG,HDL,LDL,SOD and GSH between two groups.MDA decreased by 65.49% vs 31.99%（P〈0.05）,SOD increased by 56.02% vs 31.61%（P〈0.05）;GSH increased by 9.51% vs 3.36% in intervention group and placelo group respec tively.Compared to placebo group,C-reactive protein in intervention group decreased significantly（P〈0.05=.Conclusion Supplement with tea polyphenols and vitamin C can improve blood uric acid,lipid metabolism and oxidative stress in hyperuricemia and dyslipidemia patients.