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IL-6基因-572C/G多态性与2型糖尿病的相关性 被引量：5

The Association of IL-6 Gene 572C/G Polymorphism and Type 2 Diabetes
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摘要 目的探讨白介素-6(IL-6)基因-572C/G多态性与2型糖尿病的相关性。方法应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,对358例2型糖尿病患者(2型糖尿病组)和326例非糖尿病对照人群(对照组)的IL-6基因-572C/G多态性基因型进行对照分析。结果 IL-6基因-572GG基因型在2型糖尿病组和对照组的频率分别为4.7%和1.84%(χ2=4.797,P=0.029),两组间有统计学差异。结论 IL-6基因-572GG型可能是2型糖尿病的易感基因之一。 Objective To investigate the correlation of interleukin-6（IL-6）gene 572C/G polymorphism with type 2 diabetes in Liaoning Han population.Methods Polymerase chain reaction（PCR）-restriction fragment length polymorphism（RFLP）was used to determine the distribution of allele and genotype frequencies of IL-6 gene 572C/G polymorphism in 358 type 2 diabetes mellitus（T2DM） patients and 326 cases without diabetes mellitus as control group.Case-contrast analysis was used to study the IL-6 gene 572C/G polymorphism.Results The frequence of IL-6 gene 572GG genotype in T2DM and control groups were 4.7% and 1.84%,and there was a significant difference between the two groups（χ2=4.797,P =0.029）.Conclusion IL-6 gene 572GG genotype may be a high risk of T2DM.
作者 王玉霞 孔令芳 王雪鹰 宋玉萍 柳越
机构地区 中国医科大学附属第一医院内分泌科
出处 《中国医科大学学报》 CAS CSCD 北大核心 2010年第12期1045-1047,1054,共4页 Journal of China Medical University
基金 辽宁省教育厅高校科研计划项目(20061009)
关键词 2型糖尿病 白介素-6基因 基因多态性 type 2 diabetes mellitus interleukin-6 gene gene polymorphism
分类号 R587.1 [医药卫生—内分泌] R394.3 [医药卫生—医学遗传学]
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参考文献10

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共引文献12

同被引文献76

  • 1刘群,梁群,严红,王建刚.IL-10基因多态性与乙肝肝硬化易感性的相关性研究[J].临床肝胆病杂志,2007,23(3):181-183. 被引量：5
  • 2刘秀娟,陈香美,孙雪峰,丁瑞,洪权,吕杨,姜宏卫.中国北京市区健康人群白细胞介素6基因启动子区基因的多态性及与亚裔和高加索人群的比较[J].中国临床康复,2005,9(19):116-118. 被引量：8
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引证文献5

二级引证文献26

中国医科大学学报
2010年 第12期

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