结直肠癌组织中MG7的表达及其临床意义

MG7 Expression in the Colorectal Carcinomatous Tissues and its Clinical Significance

为探讨结直肠癌组织中MG7的表达及其与临床因素的关系，本研究采用免疫组化法检测273例结直肠癌组织中MG7的表达水平，并分析其与年龄、性别、组织分化程度、TNM分期及5年生存率的关系。结果显示，273例结直肠癌组织中，MG7的阳性表达率为83．15％（227／273）。MG7的表达与患者年龄、性别及M分期无相关性（P〉0．05），而与组织分化程度、T分期、N分期及5年生存率密切相关（P〈0．05）。结果表明，检测结直肠癌组织中MG7的表达对了解结直肠癌的生物学行为和判断患者预后有重要价值。

The objective of the study was to observe the relationship between MG7 expression in colorectal carcinomatous tissues and clinical factors. Immunohistochemistry was applied in the measurement of the MG7 expression in the colorectal carcinomatous tissues of 273 patients. The MG7 expression status and its relationship with age, gender, differentiation, TNM staging and 5-year survival rate were analized. As results, the positive expression rate of MG7 was 83.15G （227/273）, there was no correlation between MG7 expression and age,gender and M staging（ P 〉0.05）, but there was close correlation between MG7 expression and tissue differentiation, T staging, N staging and 5-year survival rate（ P 〈0.05）. It is concluded that MG7 expression is of important value in observing the biological behaviour of colorectal carcinoma and predicting the prognosis.