麻黄碱预处理对顺式阿曲库铵肌松时效的影响

Effects of preadministration of ephedrine on onset time of cisatracurium

目的观察麻黄碱预处理对顺式阿曲库铵肌松时效的影响。方法选择50例ASAⅠ或Ⅱ级择期手术患者,随机均分为两组:观察组麻黄碱70μg/kg静注后4min内给予顺式阿曲库铵;对照组静注相同剂量的生理盐水后给予顺式阿曲库铵。比较两组的肌松起效时间、肌松恢复时间和插管期间的血流动力学变化。记录入室后安静≥10min诱导前(T0,基础值)、插管即刻(T1)、插管后1min(T2)和插管后3min(T3)的MAP和HR。结果与对照组比较,观察组肌松起效时间显著缩短(P<0.01);95%恢复时间显著缩短(P<0.05)。与T0时比较,T2时观察组MAP明显升高,HR明显增快(P<0.05);T1、T2时对照组MAP明显降低,HR明显减慢(P<0.05或P<0.01)。结论静注麻黄碱70μg/kg预处理后≤4min时,再给予顺式阿曲库铵可有效缩短肌松起效时间和95%恢复时间。

Objective To evaluate the effect of preadministration of ephedrine on the onset time of cisatracurium（Cis）. Methods Fifty patients were randomly allocated into two groups：The study group received ephedrine 70 μg/kg at 4 min before Cis administration;The control group received saline at 4 min before Cis administration. The onset time and 95% of recovery time of Cis,the hemodynamic of peri-intubation were recorded. Results Compared with the control group,the onset time（P0.01） and 95% of recovery time of cisatracurium（P0.05） in the study group was significantly shorter. at T2 the MAP and HR postintubation increased obviously in study group than that at T0（P0.05）;otherwise,at T2 the MAP and HR postintubation decreased obviously in control group（P0.05）,the MAP and HR during intubation decreased obviously in control group（P0.01）. Conclusion Ephedrine 70 μg/kg preadminstration can reduce the onset time and 95% of recovery time of cisatracurium effectively if cisatracurium is administered at 4 min following the ephedrine injection.