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D-二聚体检测用于诊断急性静脉血栓栓塞症的意义 被引量：15

The diagnosis value of D-dimer in acute venous thromboembolism
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摘要 D-二聚体是交联纤维蛋白经纤溶酶作用后的终末产物。只要机体血管内有活化的血栓形成及纤维溶解活动,D-二聚体就会升高。D-二聚体检测阴性可用于急性静脉血栓栓塞症(VTE)的排除诊断;特殊情况下,D-二聚体阳性结合临床表现可用于急性VTE的诊断。此外,D-二聚体的监测还可反映急性VTE药物抗凝溶栓治疗的效果以及评价VTE复发的危险程度及预后。老年、肿瘤、孕妇等特定人群的D-二聚体普遍偏高,VTE诊断的D-聚体截断值应作适当的调整,以调高D-聚体的诊断效率。 D-dimer is the end products derived from cross-linked fibrin acted on by plasmin.As long as there is activated intravascular thrombosis and fibrinolytic activity in the body,the lever of D-dimer would rise.D-dimer negative can exclude diagnosis of acute venous thromboembolism（VTE）;D-dimer positive combined with clinical manifestations can diagnose acute VTE in special cases.In addition,monitoring D-dimer can reflect the effects of anticoagulant and thrombolytic drugs treating acute VTE,and can evaluating the risk factor of recurrence and prognosis of VTE.The lever of D-dimer in old people,patients with cancer,pregnant women and other specific groups are generally high,therefore,cutoff value of D-dimer for diagnosis VTE should be appropriately adjusted in order to increase diagnostic efficiency of D-dimer.
作者 张矛 赵渝
机构地区 重庆医科大学附属第一医院血管外科
出处 《中国实用外科杂志》 CSCD 北大核心 2010年第12期1011-1014,共4页 Chinese Journal of Practical Surgery
关键词 D-聚体 静脉血栓栓塞症 D-dimer venous thromboembolism
分类号 R6 [医药卫生—外科学]
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参考文献19

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二级参考文献23

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共引文献39

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引证文献15

二级引证文献73

中国实用外科杂志
2010年 第12期

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